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Except two algal sequences having a CPYC active site, mPGES-2s have usually a very conserved CPFC motif found around the position 110 owing to the presence of the N-terminal membrane-anchoring region

10.1093/intimm/dxx031 Int Immunol

Treatment with divalent cations (e.g., iron and copper) leads to the formation of -synuclein oligomers in the presence of DOPAL (dopamine aldehyde or 3,4-Dihydroxyphenylacetaldehyde), which is a neurotoxic product of dopamine metabolization